The hotel is located in front of the tourist harbour of  Cagliari, very close to Via Roma and the beating heart of the city. Its privileged position makes it the perfect starting point for visiting the main tourist attractions located in the four historic districts of Marina, Stampace, Castello, and Villanova. Within walking distance are the Bastione di Sant Remy, the Torre degli Elefanti and that of San Pancrazio, the Roman amphitheatre, the botanical garden, and the Citadel of Museums. Not forgetting the stunning Poetto beach, a lively coastline offering a wide range of activities for indulging in la dolce vita or playing sports, which is just 10-minute drive from the hotel.

Hotel Palazzo Tirso Cagliari – MGallery is 10 km from  Cagliari-Elmas Airport, 1 km from the railway station, and 500 m from the maritime station. The Ichnusa pier, equipped for yachts, is just 350 m away. Nearby there are also several stops for the local public transport.